slot terbaru slot gacor 4d
TY - JOUR AU - Barbara Nowak AU - Alicja Braniewska AU - Monika Zadro┼╝na PY - 2012/12/31 Y2 - 2023/01/30 TI - Distribution of calretinin-immunoreactive interneurons in dorsal part of hippocampus in animal model of depression JF - Medicina Internacia Revuo JA - mir VL - 0 IS - 99 SE - Articles DO - UR - AB - Calretinin-containing (CR+) GABAergic neurons in the dorsal part of hippocampal formation (HF), including the subiculum, Cornu Ammonis (CA1-4), and dentate gyrus (DG) were visualized with immunocytochemistry. General distribution of CR+ cells was similar in each studying group. Olfactory bulbectomy caused significant increase in CR+ density in stratum oriens of CA1 and stratum moleculare of suprapyramidal blade of DG (three times, p<0.05 and twice, p=0.05, respectively), and tendency to increase in majority of other sub-regions of HF. CR+ cells were generally resistant to administration of amitriptyline as an antidepressant following bulbectomy, although the tendency of increase in CR+ cell density can be observed in CA1. Our findings indicate CR+ neurons site-specific response to bulbectomy model of depression. This could involve the trisynaptic pathway and temporo-ammonic tract by controlling other interneurons terminating on different compartments of principal cells.  ER -