Distribution of calretinin-immunoreactive interneurons in dorsal part of hippocampus in animal model of depression
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Keywords

bulbectomy
calretinin
hippocampus
interneuron

How to Cite

1.
Nowak B, Braniewska A, Zadrożna M. Distribution of calretinin-immunoreactive interneurons in dorsal part of hippocampus in animal model of depression. mir [Internet]. 31Dec.2012 [cited 1Dec.2021];(99):35-0. Available from: https://interrev.com/mir/index.php/mir/article/view/98

Abstract

Calretinin-containing (CR+) GABAergic neurons in the dorsal part of hippocampal formation (HF), including the subiculum, Cornu Ammonis (CA1-4), and dentate gyrus (DG) were visualized with immunocytochemistry. General distribution of CR+ cells was similar in each studying group. Olfactory bulbectomy caused significant increase in CR+ density in stratum oriens of CA1 and stratum moleculare of suprapyramidal blade of DG (three times, p<0.05 and twice, p=0.05, respectively), and tendency to increase in majority of other sub-regions of HF. CR+ cells were generally resistant to administration of amitriptyline as an antidepressant following bulbectomy, although the tendency of increase in CR+ cell density can be observed in CA1. Our findings indicate CR+ neurons site-specific response to bulbectomy model of depression. This could involve the trisynaptic pathway and temporo-ammonic tract by controlling other interneurons terminating on different compartments of principal cells.

 

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