Znaczenie niedoboru i nadmiaru żelaza w organizmie człowieka w patogenezie wybranych chorób systemowych


Iron deficiency
Iron deficiency anemia
reactive oxygen species

How to Cite

Stawarz-Janeczek M, Szczeklik K, Muszyńska B, Pytko-Polończyk J. Znaczenie niedoboru i nadmiaru żelaza w organizmie człowieka w patogenezie wybranych chorób systemowych. mir [Internet]. 25Mar.2024 [cited 23May2024];30(121):231-7. Available from: https://interrev.com/mir/index.php/mir/article/view/228


Iron is a microelement necessary for the functioning of most organisms. Maintaining proper iron homeostasis is extremely important because both its deficiency and excess are harmful to the body.

The aim of the study was to present the importance of the role of iron in the pathogenesis of diseases caused by its deficiency or excess.

According to estimates, about 30% of the global population has health problems due to iron deficiency, which is the main cause of anemia. Excess iron in the body, caused by a genetic disorder of its absorption and, more often, other reasons, stimulates oxidative stress with the formation of active hydroxyl radicals with subsequent damage to cells and organs, as well as cell death dependent on iron metabolism – ferroptosis. A number of diseases that involve overloading the body with this element may be related to ferroptosis, causing cancer, neurodegenerative diseases, ischemia-reperfusion damage, and damage to the kidneys and gastrointestinal tract, including the liver, pancreas or lungs.



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