Role of TCD emboli-monitoring in evaluation of efficacy of anticoagulant therapy in patients with nonvalvular atrial fibrillation
Vol 28 No 111 (2018), Short article
Vol 28 No 111 (2018)

Role of TCD emboli-monitoring in evaluation of efficacy of anticoagulant therapy in patients with nonvalvular atrial fibrillation

Short article
Published December 31, 2018
V Nosáľ
Neurology Clinic, Jessenius Faculty of Medicine Commenius University, Slovakia
E Kurča
Neurology Clinic, Jessenius Faculty of Medicine Commenius University, Slovakia
F Nehaj
Ist Internal Clinic, Jessenius Faculty of Medicine Commenius University, Slovakia
M Mokáň
Ist Internal Clinic, Jessenius Faculty of Medicine Commenius University, Slovakia
L Jamrišková
Ist Internal Clinic, Jessenius Faculty of Medicine Commenius University, Slovakia
E Kantorová
Neurology Clinic, Jessenius Faculty of Medicine Commenius University, Slovakia
P Kubatka
Department of Medical Biology, Jessenius Faculty of Medicine, Comenius University, Martin, Slovakia. Division of Oncology, Biomedical Center Martin, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin, Slovakia
J Strnádel
Division of Molecular Medicine, Biomedical Center Martin, Jessenius Faculty of Medicine Commenius University, Slovakia
M Grendár
Department of Bioinformatics, Biomedical Center Martin, Jessenius Faculty of Medicine Commenius University, Slovakia
Š Sivák
Neurology Clinic, Jessenius Faculty of Medicine Commenius University, Slovakia
Cover of MIR - number 111, volume 28, year 2018
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Keywords

emboli-monitoring
atrial fibrilation
stroke prevention
TCD

How to Cite

1.
Nosáľ V, Kurča E, Nehaj F, Mokáň M, Jamrišková L, Kantorová E, Kubatka P, Strnádel J, Grendár M, Sivák Š. Role of TCD emboli-monitoring in evaluation of efficacy of anticoagulant therapy in patients with nonvalvular atrial fibrillation. mir [Internet]. 31Dec.2018 [cited 19May2019];28(111):78-1. Available from: https://interrev.com/mir/index.php/mir/article/view/140
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Abstract

Background: Atrial fibrillation (AF) is a risk factor for stroke but, despite anticoagulation therapy, the risk of stroke is not completely eliminated. We evaluated the presence of microembolic signals (MES) by TCD emboli-monitoring in AF patients receiving various anticoagulation therapies.

Methods: In total, 103 patients were divided into four therapeutic groups (receiving warfarin, dabigatran, rivaroxaban, or apixaban; 22 patients in each group) and a control group (15 patients). Common stroke risk factors were evaluated, such arterial hypertension, ischemic heart disease, history of TIA/stroke, diabetes mellitus, and hyperlipidemia. TCD emboli-monitoring was performed on bilateral middle cerebral arteries  for 45-60 minutes.

Results: No statistically significant differences were determined regarding the presence of risk factors between all groups. We found 2 MES in the warfarin group, 1 in the rivaroxaban group, 4 in the dabigatran group, and 0 in the apixaban group. One patient had positive MES in the control group. No statistical differences were seen when the groups were compared with the control group or with each other.

Conclusions: TCD emboli-monitoring can be used for MES detection in patients with AF receiving anticoagulation therapy and thus for the identification of patients at high risk of stroke occurrence/reoccurence.

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