Medicina Internacia Revuo - International Medicine Review <p><strong><em>Medicina Internacia Revuo</em></strong> is an international journal with a long tradition – going back to 1923. It is an official forum of the Universala Medicina Esperanto Asocio for communicating results and ideas in medical science. The journal publishes reviews, original research papers and expert commentaries within a wide range of topics in pharmaceutical and health sciences. Published articles are written in congress languages with English and Esperanto abstracts.&nbsp;The journal&nbsp;is published twice a year in paper and electronic versions.</p> UMEA SHINODA KURACEJO en-US Medicina Internacia Revuo - International Medicine Review 0465-5435 The use of sulfonamides in the pharmacotherapy of infectious diseases of humans and animals and the associated environmental risk <p>Sulfonamides are one of the oldest antibacterial drugs that remain still in use in humans and animals treatment. These compounds block the biosynthesis of folate in bacterial cells, thus inhibiting growth of bacteria. In order to potentiate the pharmacological activity, sulfonamides are often combined with trimethoprim. The role of those bacteriostatic agents has decreased over the years, mainly due to increasing bacterial resistance which is an effect of the inappropriate use of sulfonamides. There are still several compounds which are administered in humans to treat not only bacterial infections, but also protozoan ones (e.g. toxoplasmosis), for instance sulfamethoxazole, sulfacetamide, sulfathiazole. More number of sulfonamides is used in veterinary. According to this fact, there is a considerable adverse effect of those compounds on the environment: sulfonamides, after having been excreted from animal organisms, are present in soil and water, including groundwater. Hence there is a strong need to find effective methods of sulfonamides degradation in order to protect the environment</p> Adrian Podkowa Anna Włodarczyk Włodzimierz Opoka Bożena Muszyńska ##submission.copyrightStatement## 2018-08-17 2018-08-17 28 110 4 10 The influence of ketoprofen and zinc oxide nanoparticles on serum copper level in rats. <p><em>Copper is a trace element, both with pro-inflammatory and anti-inflammatory activity. The role of copper in anti-inflammatory response includes several mechanisms. Antagonism between zinc (Zn) and copper (Cu) and proper balance between the two elements in the organism may affect the course of inflammatory diseases. Copper is a component of Zn/Cu superoxide dismutase (Zn/Cu SOD) and other enzymes involved in the anti-inflammatory response of the organism. To investigate the serum copper level during inflammation and diseases, numerous researches were conducted. Copper deficiency or copper intoxication may lead to biological consequences. Copper deficiency may be caused by various factors, one of them is excessive zinc supplementation. Antagonism between zinc and copper and proper balance between the two elements in the organism may affect the course of inflammatory diseases. </em><em>The aim of the study was to investigate the alterations in the serum copper level after 2-week zinc oxide nanoparticle (NPs-ZnO) administration. Zinc oxide nanoparticles were administered in the following doses: 7 or 14 mg/kg, per os(p.o.) or intraperitoneally (i.p.). The second aim was to investigate serum copper level alterations after 2-week NPs-ZnO and single ketoprofen administration in the following three doses: 5, 10, and 20 mg/kg, p.o. The inflammatory state was induced in each group by the carrageenan injection at the 15th day of the experiment. The results indicate for the decrease in serum copper level in group receiving NPs-ZnO in a dose 14 mg/kg i.p., compared to control. Moreover, in groups receiving NPs-ZnO in the doses 14 mg/kg i.p., 7 and 14 mg/kg p.o. as well as ketoprofen in a dose 20 mg/kg p.o., a decrease in serum copper level was observed. In case of p.o. administration of NPs-ZnO, no significant differences in serum copper level were observed, compared to control. We may conclude that NPs-ZnO administration and also ketoprofen administration acts as anti-inflammatory agents and may induce a decrease in serum copper level.</em></p> Magdalena Olbert Mirosław Krośniak Joanna Gdula-Argasińska Tadeusz Librowski Małgorzata Zygmunt ##submission.copyrightStatement## 2018-08-17 2018-08-17 28 110 11 22 Pharmacological evaluation of pyrrolidines as potent α1-adrenergic receptor antagonist with uro-selective profile <p><em>Continuing our efforts in developing potent α<sub>1</sub>-adrenoceptor antagonists with uroselective profile, a series of </em><em>derivatives</em> <em>of</em> <em>pyrrolidines</em><em> was</em><em> biologically evaluated in vitro for their affinity for </em><em>α1- and α<sub>2</sub>-adrenoceptor</em><em>s</em><em>. Result from binding assays allowed the identification of compounds with the highest affinity and selectivity for α<sub>1</sub></em><em>-adrenoceptors behaving as potent antagonists at those sites in</em><em> cellular functional assays. </em><em>Among tested derivatives, compound </em><strong><em>V </em></strong><em>[</em><em>1-(3-(4-(3-chlorophenyl)piperazin-1-yl)propyl)pyrrolidin-2-one]</em><em>, </em><em>displayed a 152-fold functional preference to </em><em>α</em><em><sub>1A</sub></em><em>-</em><em>adrenoceptor versus </em><em>α</em><em><sub>1B </sub></em><em>subtype</em><em>. Finally, the most promising&nbsp; </em><em>compound </em><em>V</em><em> at the doses of 2, 5 and 10 mg/kg after i.v.</em> <em>administered</em><em>, in contrast to tamsulosin (at a dose of 2 mg/kg, i.v.) did not significantly decrease systolic and diastolic blood pressure in normotensive anesthetized rats.</em><em> This selected </em><em>α</em><em><sub>1A</sub></em><em>-</em><em>adrenoceptor antagonist with </em><em>stronger</em><em> uroselective profile,</em> <em>requires further research.</em></p> Jacek Sapa Marek Bednarski Leszek Nowiński Magdalena Kotańska Joanna Knutelska Paula Zaręba Anna Lechocka-Nowak Małgorzata Zygmunt Małgorzata Belczyk ##submission.copyrightStatement## 2018-08-17 2018-08-17 28 110 23 33 Anxiolytic-like activity of PZ-1433, a novel arylsulfonamide derivative of aryloxy(propyl)piperidine, in rodents <p>A novel arylsulfonamide derivative of aryloxy(propyl)piperidine PZ-1433, has been proved to possess a preclinical activity profile appropriate for the treatment of depression and memory impairments. In the present study its pharmacological activity toward anxiety symptoms as well as its anxiolytic properties have been examined in mouse and rat models. PZ-1433 significantly increased the number of punished crossings and decreased the number of buried marbles in two tests conducted in mice. Moreover, PZ-1433 evoked anxiolytic-like activity in “conditional” anxiety paradigm in rats, meaningly increasing the number of accepted shocks in the Vogel conflict drinking test. However, it did not produce a significant anxiolytic-like effect in “unconditional” anxiety model, i.e. the elevated plus-maze test. From these results, it is likely that direct antagonism toward serotonin 5-HT<sub>7</sub> receptors may be involved in the anxiolytic action of PZ-1433. However, inhibition of serotonin transporter evoked by PZ-1433 and detected <em>in vitro</em>, might also contribute to this effect.</p> Anna Partyka Magdalena Jastrzębska-Więsek Vittorio Canale Paweł Zajdel Anna Wesołowska ##submission.copyrightStatement## 2018-08-17 2018-08-17 28 110 35 46 On Two Painters and Eleven Doctors <p>Two famous Jewish painters, the German Max Lieberman (1847-1935) and the Dutch Jozef Israëls ( 1824 – 1911), were close friends. They both painted physicians who were their close acquaintances. This article pays tribute to these two painters and the physicians they immortalized in their paintings.</p> Avi Ohry, Professor Emeritus ##submission.copyrightStatement## 2018-08-17 2018-08-17 28 110 47 54