Selective serotonin reuptake inhibitors (SSRIs) are the frontline class of antidepressant drugs. They are widely used because of their safety, tolerability, and demonstrated efficacy. In this review, we are pointing at other indications of SSRIs – apart from depression.This article is based on a selective review of the relevant literature retrieved by a PubMed search and ScienceDirect search. The results of electronic searches show SSRIs to be of great importance in pharmacotherapy of many conditions outside depression. Medical literature supports the use of SSRIs for the treatment of premature ejaculation (especially short-acting SSRI – dapoxetine), eating disorders (especially bulimia nervosa and binge eating disorder), obsessive-compulsive disorder and social anxiety disorder.