Abstract
Obesity, which occurs both in rich as well as developing countries, is a chronic disease that can cause many serious illnesses. It has become a global health problem, which a ects one- third of adult population in the world. To induce weight loss, profound lifestyle modi cation is required. In the case, when lifestyle changes alone are insu cient, pharmacotherapy can be helpful. Most of anti-obesity drugs (e. g. fen uramine, sibutramine, rimonabant), which have been approved for treatment of obesity, were subsequently withdrawn from the market due to their adverse e ects. In this manuscript, a short overview of currently available anti-obesity drugs like orlistat, lorcaserin, liragutide as well as phentermine/topiramate and naltrexone/ bupropion combination, was presented. Herein we focus on e ciency, mechanism of action and possible side e ects of anti-obesity drugs. Finally, it was emphasized that be er understanding of mechanisms involved in appetite regulation could be useful for developing novel, more e ec- tive and be er tolerated anti-obesity drugs.