Evaluation of anti-manic activity of pregabalin in a mouse model of methylphenidate-induced mania

  • Natalia Malikowska Department of Pharmacodynamics, Faculty of Pharmacy, Jagiellonian University, Medyczna 9, PL 30-688 Cracow
  • Anna Grzywa Department of Pharmacodynamics, Faculty of Pharmacy, Jagiellonian University, Medyczna 9, PL 30-688 Cracow
  • Joanna Śladowska Department of Pharmacodynamics, Faculty of Pharmacy, Jagiellonian University, Medyczna 9, PL 30-688 Cracow
  • Kinga Sałat Department of Pharmacodynamics, Faculty of Pharmacy, Jagiellonian University, Medyczna 9, PL 30-688 Cracow
  • Tadeusz Librowski Department of Radioligands, Faculty of Pharmacy, Jagiellonian University, Medyczna 9, PL 30-688 Cracow
  • Joanna Gdula-Argasińska Department of Radioligands, Faculty of Pharmacy, Jagiellonian University, Medyczna 9, PL 30-688 Cracow

Abstract

Mania is a psychiatric disorder which may occur alternately with depression as a bipolar disorder, or much less often as an individual disease. It might be accompanied by other disorders, i.e. schizophrenia, dementia or withdrawal syndrome. Only a few effective drugs are used for the treatment of mania. Patients suffering from bipolar disorder are treated with mood-stabilizing drugs, administered during the course of the disease, and drugs that are implemented when mania or depression episodes occur. Some studies report effectiveness of anticonvulsant drugs in the cessation of mania, thus in our study we assessed the effectiveness of pregabalin in a mouse model of mania induced by administration of metylphenidate (5 mg/kg; s.c). Pregabalin was tested in the forced swim test (75 mg/kg, 100 mg/kg; i.p.) and the elevated plus maze test (75 mg/kg; i.p.) to assess its antidepressant-like and anxiolytic-like properties, respectively. In the elevated plus maze in MPH-treated mice pregabalin significantly reduced time spent in open arms (p<0.001 vs. MPH-treated control). In the forced swim test MPH compared to vehicle significantly (p<0.001) reduced duration of immobility. In MPH-treated mice pregabalin partially reversed this effect of MPH. This effect was significant only for the dose of 75 mg/kg (p<0.05). In the rotarod test neither MPH, nor its combination with pregabalin (75 mg/kg; 100 mg/kg) influenced motor coordination of mice at any speed tested. To conclude our study revealed that pregabalin might reverse manic-like action of MPH related to hyperlocomotion, which may indicate for its possible effectiveness in mania episodes.

Published
2017-06-30
How to Cite
MALIKOWSKA, Natalia et al. Evaluation of anti-manic activity of pregabalin in a mouse model of methylphenidate-induced mania. Medicina Internacia Revuo - International Medicine Review, [S.l.], n. 108, p. 196-201, june 2017. ISSN 0465-5435. Available at: <http://interrev.com/mir/index.php/mir/article/view/19>. Date accessed: 11 dec. 2017.
Section
Articles