Antidepressant-like and anxiolytic-like activity of a novel indole amine derivative ADN-2013 in rodents

  • Anna Wasik Faculty of Pharmacy, Medical College, Jagiellonian University, 9 Medyczna St., 30-688 Kraków, Poland
  • Anna Partyka Faculty of Pharmacy, Medical College, Jagiellonian University, 9 Medyczna St., 30-688 Kraków, Poland
  • Magdalena Jastrzębska-Więsek Faculty of Pharmacy, Medical College, Jagiellonian University, 9 Medyczna St., 30-688 Kraków, Poland
  • Marcin Kołaczkowski Faculty of Pharmacy, Medical College, Jagiellonian University, 9 Medyczna St., 30-688 Kraków, Poland. Adamed Ltd., Pieńków 149, 05-152 Czosnów, Poland
  • Anna Wesołowska Faculty of Pharmacy, Medical College, Jagiellonian University, 9 Medyczna St., 30-688 Kraków, Poland

Abstract




A novel indolamine derivative, ADN-2013, has been proved to possess a preclinical activity pro le appropriate for the treatment of behavioral and psychological symptoms of dementia. Its antidepressant and anxiolytic properties have been examined in rat and mice models. The receptor mechanisms underlying the antidepressant properties of ADN-2013 have also been elucidated. ADN-2013 signi cantly shortened the immobility time measured in the forced swim test in mice and rats, producing an e ect that was abolished by the dopamine D1-receptor antagonist SCH 23390 in rats. Moreover, ADN-2013 evoked anxiolytic-like activity in both “conditional” and “unconditional” anxiety-like paradigms in mice and rats. From these re- sults, it is likely that direct antagonism toward serotonin 5-HT6 receptors and an indirect e ect of dopamine, acting mostly via D1-like receptors, may be involved in the antidepressant action of ADN-2013. However, the partial agonist activity of ADN-2013 toward D2 receptors, observed in in vitro studies, might also contribute to this effect.




Published
2017-06-30
How to Cite
WASIK, Anna et al. Antidepressant-like and anxiolytic-like activity of a novel indole amine derivative ADN-2013 in rodents. Medicina Internacia Revuo - International Medicine Review, [S.l.], n. 108, p. 152-156, june 2017. ISSN 0465-5435. Available at: <http://interrev.com/mir/index.php/mir/article/view/12>. Date accessed: 11 dec. 2017.
Section
Articles