The role of adenosine A2A receptors in antidepressant activity in experimental animal model of depression

  • Anna Dziubina Department of Pharmacodynamics, Faculty of Pharmacy, Jagiellonian University, Medical College, Medyczna 9, 30-688 Cracow, Poland
  • Małgorzata Zygmunt Department of Pharmacodynamics, Faculty of Pharmacy, Jagiellonian University, Medical College
  • Barbara Filipek Department of Pharmacodynamics, Faculty of Pharmacy, Jagiellonian University, Medical College, Medyczna 9, 30-688 Cracow, Poland
  • Kinga Sałat Department of Pharmacodynamics, Faculty of Pharmacy, Jagiellonian University, Medical College, Medyczna 9, 30-688 Cracow, Poland
  • Adrian Bryła Department of Pharmacodynamics, Faculty of Pharmacy, Jagiellonian University, Medical College, Medyczna 9, 30-688 Cracow, Poland
  • Tadeusz Librowski 2Department of Radioligands, Faculty of Pharmacy, Jagiellonian University, Medical College, Medyczna 9, 30-688 Cracow, Poland
  • Joanna Gdula-Argasińska Jagiellonian University Medical College, Faculty of Pharmacy, Department of Radioligands

Abstract

Intensive studies on the role of adenosine A2A receptors in Parkinson's disease have been carried out for many years,. These studies have indicated that the antagonists of these receptors not only alleviate motor deficits but also exhibit neuroprotective effects in various animal models. Little is known about the role of these receptors in ailments accompanying Parkinson's disease, such as depression and anxiety. This paper provides a summary of existing research on the role of A2A receptors in comorbid depression in Parkinson's disease.

Published
2017-12-31
How to Cite
DZIUBINA, Anna et al. The role of adenosine A2A receptors in antidepressant activity in experimental animal model of depression. Medicina Internacia Revuo - International Medicine Review, [S.l.], v. 27, n. 109, p. 228-236, dec. 2017. ISSN 0465-5435. Available at: <http://interrev.com/mir/index.php/mir/article/view/112>. Date accessed: 22 apr. 2018.
Section
Review publication