Med.Inter.Rev. 2016, 106, 20-25.

A review of medications used for treatment of obesity


Katedra Chemii Farmaceutycznej, Uniwersytet Jagielloński Collegium Medicum, ul. Medyczna 9, 30-688

Obesity, which occurs both in rich as well as developing countries, is a chronic disease that can cause many serious illnesses. It has become a global health problem, which affects onethird of adult population in the world. To induce weight loss, profound lifestyle modification is required. In the case, when lifestyle changes alone are insufficient, pharmacotherapy can be helpful. Most of anti-obesity drugs (e. g. fenfluramine, sibutramine, rimonabant), which have been approved for treatment of obesity, were subsequently withdrawn from the market due to their adverse effects. In this manuscript, a short overview of currently available anti-obesity drugs like orlistat, lorcaserin, liragutide as well as phentermine/topiramate and naltrexone/ bupropion combination, was presented. Herein we focus on efficiency, mechanism of action and possible side effects of anti-obesity drugs. Finally, it was emphasized that better understanding of mechanisms involved in appetite regulation could be useful for developing novel, more effective and better tolerated anti-obesity drugs.

Keywords: obesity, overweight, obesity pharmacoteraphy

Oryginal language: Polish

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