Med.Inter.Rev. 2012, 99, 35-40.

Distribution of calretinin-immunoreactive interneurons in dorsal part of hippocampus in animal model of depression

Barbara NOWAK1, Alicja BRANIEWSKA1, Monika ZADROŻNA1

1.Department of Pharmacobiology, Medical College, Jagiellonian University, 30-688 Cracow, Medyczna str. 9, Poland.


Calretinin-containing (CR+) GABAergic neurons in the dorsal part of hippocampal formation (HF), including the subiculum, Cornu Ammonis (CA1-4), and dentate gyrus (DG) were visualized with immunocytochemistry. General distribution of CR+ cells was similar in each studying group. Olfactory bulbectomy caused significant increase in CR+ density in stratum oriens of CA1 and stratum moleculare of suprapyramidal blade of DG (three times, p<0.05 and twice, p=0.05, respectively), and tendency to increase in majority of other sub-regions of HF. CR+ cells were generally resistant to administration of amitriptyline as an antidepressant following bulbectomy, although the tendency of increase in CR+ cell density can be observed in CA1. Our findings indicate CR+ neurons site-specific response to bulbectomy model of depression. This could involve the trisynaptic pathway and temporo-ammonic tract by controlling other interneurons terminating on different compartments of principal cells.

Keywords: reactive oxygen species ROS, reactive nitrogen species RNS, physiological process regulation, redox balance, hormesis, free radiclas

Oryginal language: Polish

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